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Last Updated: 06/05/2026

4basebio

Cambridge
Founded 2019
GMP-grade cell-free synthetic DNA for genetic medicines

4basebio is a biotechnology manufacturing company producing GMP-grade synthetic DNA for use in cell and gene therapies, mRNA vaccines and genome editing applications.

Using an enzymatic, cell-free synthesis process, the company manufactures application-specific linear DNA constructs that overcome the purity and scalability limitations of conventional plasmid-based systems.

4basebio holds MHRA GMP certification for clinical-grade manufacture and also develops non-viral nanoparticle delivery systems for genetic medicine applications.