Company Directory

Full service clinical trial and real-world evidence study management

O4 Research is a Belfast-based clinical research and site management organisation delivering full service and functional clinical trial services to pharmaceutical, biotechnology and consumer health companies across the UK, Ireland and Europe. The company specialises in late-phase clinical trials and non-interventional real-world evidence studies, offering services spanning concept development, study design, patient recruitment, clinical monitoring, regulatory submissions, medical writing, and data management.

Specialist CRO for rare disease drug development and commercialisation

TMC Pharma Services is a contract research organisation specialising in drug development support for rare and orphan diseases. The company serves small and mid-sized biotech and biopharma clients across the full development lifecycle, providing regulatory affairs, clinical development, pharmacovigilance, medical services, quality management, and drug commercialisation services including marketing authorisation holder functions. Therapeutic areas of focus include oncology, rare neurological disorders, respiratory disease, and haematology.

Full-service CRO and pharmacovigilance services for biopharma

Ergomed is a global contract research organisation providing clinical development, pharmacovigilance, and regulatory compliance services to the pharmaceutical and biotechnology industries. Operating across more than 100 countries, the group manages Phase I to IV clinical trials with particular depth in oncology and rare disease programmes. Its portfolio of service brands includes Ergomed Clinical Research, PrimeVigilance for post-marketing drug safety, and ADAMAS Consulting for GxP auditing.

Global clinical research organisation providing consultant support for trials

Momentum Pharma is a company providing clinical trial consultants and functional service provider solutions to biotech, pharmaceutical and CRO clients globally. Operating as an alternative to traditional full-service CROs, it supplies embedded clinical research associates, programme managers and regulatory specialists on a flexible basis, with expertise spanning oncology, rare disease, haematology and neuroscience. The company operates across 45 countries and was recognised with a King's Award for Enterprise for international trade in 2022.

Global CRO delivering outsourced clinical development and safety services

ICON plc is a contract research organisation providing outsourced clinical development and commercialisation services to pharmaceutical, biotechnology, and medical device companies worldwide. The company supports the full product development lifecycle, from early-phase studies through to post-market safety monitoring. UK operations are based across sites in Swansea, Reading, and Livingston, with the Swansea hub specialising in clinical research services including pharmacovigilance.

Enzyme indicator technology for hydrogen peroxide bio-decontamination

Protak Scientific manufactures Enzyme Indicator technology, a rapid validation tool for measuring hydrogen peroxide gaseous bio-decontamination efficacy in pharmaceutical manufacturing and cleanroom environments. Developed in collaboration with Public Health England, the system delivers results in 60 seconds and is used to validate aseptic isolators, pass-through chambers, and filling lines. The company also provides validation consultancy and a real-time compliance reporting platform, serving over 80% of the world's largest pharmaceutical companies.

GLP-accredited animal-free safety and efficacy testing for cosmetics and chemicals

XCellR8 is a contract research organisation providing exclusively animal-free safety and efficacy testing services to the cosmetics, personal care, and chemical industries. Operating from a GLP-accredited laboratory at Sci-Tech Daresbury, the company uses human cell culture systems to deliver regulatory tests for skin and eye irritation, skin sensitisation, corrosion, genotoxicity, and cytotoxicity, all conducted without animal-derived materials. Its methods have received regulatory recognition from OECD and ECHA.

Specialist oncology CRO for early and late phase clinical trials

Theradex (Europe) Limited is the European arm of Theradex Oncology, a US-founded CRO with over 40 years specialising in oncology clinical development. The company provides full-service clinical trial management for pharma and biotech sponsors across early and late phase studies, with expertise in oncology, haematology, and immunology. Services include protocol design, regulatory support, site selection, monitoring, and data management. Theradex holds a long-standing contract with the US National Cancer Institute for clinical trials monitoring.

Specialist oncology clinical trial management for biotech and pharma

Karma Oncology is a specialist contract research organisation providing full-service and functional clinical trial management to biotechnology and pharmaceutical companies in oncology. Operating as a lean virtual CRO, the company offers clinical development planning, protocol design, site selection and activation, regulatory submissions, patient recruitment, and clinical monitoring. The team has experience across solid tumours, haematological malignancies, checkpoint inhibitors, and cell therapy programmes including CAR-T.

Specialist CNS and psychiatric clinical trial design and delivery organisation

Clerkenwell Health is a London-based specialist contract research organisation providing clinical trial design, regulatory submission, and trial delivery services for CNS, psychiatric, and psychedelic-assisted therapy research. The company operates a purpose-built clinical site network, including an NHS-embedded research unit in Doncaster, and provides specialist patient recruitment and therapist training for mental health and neurological trials. Clients are pharmaceutical and biotechnology companies developing treatments across depression, PTSD, anxiety, dementia, and neurodegeneration.

Preclinical CRO for pharmaceutical and agrochemical drug development

Labcorp Early Development Laboratories is a major nonclinical contract research organisation operating from its Harrogate campus in North Yorkshire. The facility provides preclinical pharmaceutical development services including safety pharmacology, toxicology, pathology, bioanalytical testing, and drug metabolism and pharmacokinetics, supporting programmes from lead optimisation through IND/CTA submission. The Harrogate site also specialises in crop protection and agrochemical product development, operating as part of Labcorp's global nonclinical network.

Biostatistics, clinical trial simulation and data science services

Exploristics is a Belfast-based provider of biostatistics, data science, and clinical trial simulation software and services to the pharmaceutical, biotechnology, medical diagnostics, and device sectors. The company supports clinical development programmes from early-phase design through to regulatory submission, offering statistical consultancy, Bayesian analysis and data monitoring committee support. Its cloud-based trial simulation software enables sponsors to optimise study design and reduce the risk of late-stage failure. Exploristics was acquired by MMS Holdings in February 2025.