Company Directory

Endometrial biology platform for implantation failure and miscarriage

Sita Bio is a London-based biotech developing a first-trimester biology platform to investigate embryo implantation failure and recurrent miscarriage. The company combines endometrial phenotyping and molecular state mapping with human uterine models incorporating hormone-responsive epithelium, stromal ECM, perfusable vasculature and immune elements. Its long-term goal is to enable precision protocol selection for IVF clinics and to identify therapeutic candidates for early pregnancy loss.

Oral iron deficiency therapy for adults across multiple indications

Shield Therapeutics is a commercial-stage specialty pharmaceutical company focused on iron deficiency. Its lead product, Accrufer/Feraccru (ferric maltol), is a non-salt-based oral iron therapy approved for the treatment of iron deficiency with or without anaemia in adults across the United States, European Union, United Kingdom, and Switzerland. The product is commercialised directly in the US via a partnership with Viatris, and licensed to Norgine for Europe, the UK, Australia and New Zealand.

Oncology biotech developing peptide therapeutics and diagnostics

ValiRx is a UK-listed biopharmaceutical company focused on the development of oncology therapeutics and companion diagnostics. The company selects and incubates novel drug candidates, including peptide-based compounds targeting prostate cancer, endometriosis, and other solid tumours, progressing them from preclinical evaluation towards clinical development and partnering. Through its subsidiary Inaphaea BioLabs, ValiRx also offers translational drug discovery services, including cell-based assays and patient-derived cell models, to academic and industry researchers.

AI-powered infrared diagnostic test for breast cancer recurrence risk

Digistain is a biotechnology company developing MHRA-cleared diagnostic technology for predicting breast cancer recurrence risk. The platform uses infrared spectrometry to generate spectroscopic signatures from tumour biopsy tissue, with AI analysis producing a personalised prognostic score indicating the likelihood of disease recurrence over ten years. The technology is designed as a faster and lower-cost alternative to transcriptomic profiling methods, enabling patient stratification for adjuvant chemotherapy decisions.

Therapeutics to restore egg quality and improve IVF outcomes

U-Ploid Biotechnologies is an early-stage biotechnology company developing first-in-class therapeutics to address age-related decline in egg quality. Its lead programme targets chromosomal instability in human oocytes which is a primary driver of IVF failure, miscarriage, and congenital disorders in women of advanced maternal age. Treatments are designed to integrate into existing assisted reproduction procedures. U-Ploid is based at the Bioescalator incubator on Oxford University's Old Road Campus.

AI-powered ultrasound analysis software for endometriosis detection

Revela is a medical software company developing machine learning tools to assist in the diagnosis of endometriosis via analysis of ultrasound scans. The software automatically identifies subtle imaging signs associated with endometriosis and returns a structured report to the reviewing clinician, targeting earlier identification in the diagnostic pathway. The company's technology is trained on retrospectively labelled, surgically validated cases and is designed to integrate into existing clinical imaging workflows without requiring additional procedures.

Tissue-level disease platform for endometriosis drug discovery

Cyclana Bio is a drug discovery company developing tissue-level therapeutics for endometriosis and women's health conditions. The company builds whole-tissue disease models using menstrual fluid collected through an observational clinical trial, combined with AI-driven multi-omic data integration to identify novel targets. Its research focuses on the role of extracellular matrix dysregulation in driving inflammation and tissue dysfunction. Cyclana Bio's platform is designed to extend beyond endometriosis into other chronic inflammatory diseases sharing similar tissue-level mechanisms.

Clinical skin microbiome testing and multi-omic ingredient analysis platform

Sequential Skin is a biotechnology company providing non-invasive clinical microbiome testing and multi-omic analysis services to the personal care and pharmaceutical industries. Using patch-based sampling and next-generation sequencing, the company quantifies how ingredients and formulations affect the skin microbiome and host biomarkers. Its proprietary dataset of over 50,000 samples and 4,000 ingredients underpins an AI-powered discovery engine for identifying and optimising next-generation bioactive compounds.

Pharmacogenomic platform for personalised hormone therapy prescribing

Dama Health is a clinical decision-support software company focused on personalised prescribing of hormone therapies in women's health. Its platform collects patient health, lifestyle, and genetic data and uses an AI-driven recommendation engine to match patients to appropriate hormone therapies and contraceptives. The platform is designed for use by OB/GYN and women's health clinicians and incorporates pharmacogenomic profiling to identify individual predispositions to hormone therapy side effects.

AI software for embryo and sperm selection in assisted reproductive technology

IVF 2.0 is a software company developing artificial intelligence tools for use in in vitro fertilisation laboratories. Its products apply computer vision and deep learning to microscopy imagery to provide quantitative assessments of embryo and sperm quality, supporting embryologists in selection decisions that are difficult to standardise by visual inspection alone. The software is deployed across more than 70 fertility clinics in over 30 countries.

Lateral flow and molecular diagnostic tests for multiple applications

AccuBio is a UK-based manufacturer of in-vitro diagnostic products, producing lateral flow assays and molecular diagnostic tests across infectious disease, toxicology, oncology, cardiovascular, and veterinary applications. Operating from manufacturing facilities in Alva, Scotland, acquired from Omega Diagnostics, the company supplies healthcare providers, laboratories, and veterinary services globally. AccuBio is a wholly owned subsidiary of Healgen Scientific, a US-based IVD group within the broader Zhejiang Orient Gene Biotech group.

Non-invasive vaginal sampling for gynaecological disease

Ellele Health is a medical research company developing a minimally invasive vaginal sampling device and associated downstream assays for the detection and management of gynaecological conditions. Using a proprietary biospecimen collected from the vaginal wall, the company applies genetic, epigenomic, and microbial analysis to explore diagnostics for gynaecological cancers and other conditions. Ellele Health is a spin-out of Origin Sciences, whose equivalent colorectal diagnostic platform underpins the technology.